| Pair Name | Curcumin, Carboplatin | ||
| Phytochemical Name | Curcumin (PubChem CID: 969516 ) | ||
| Anticancer drug Name | Carboplatin (PubChem CID: 426756 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Curcumin, Carboplatin | |||
| Disease Info | [ICD-11: 2C60] | Breast cancer | Investigative | |
| Biological Phenomena | Induction-->DNA damage | |||
| Gene Regulation | Up-regulation | Expression | ROS1 | hsa6098 |
| Down-regulation | Expression | RAD51 | hsa5888 | |
| Up-regulation | Expression | H2AX | hsa3014 | |
| In Vitro Model | CAL-51 | Breast carcinoma | Homo sapiens (Human) | CVCL_1110 |
| MDA-MB-231 | Breast adenocarcinoma | Homo sapiens (Human) | CVCL_0062 | |
| Result | Our data demonstrate that curcumin sensitizes TNBC to the anticancer effect of carboplatin by increasing ROS-induced DNA damage, thus providing an effective combination treatment strategy for TNBC. | |||
| No. | Title | Href |
|---|---|---|
| 1 | Curcumin sensitizes carboplatin treatment in triple negative breast cancer through reactive oxygen species induced DNA repair pathway. Mol Biol Rep. 2022;49(4):3259-3270. doi:10.1007/s11033-022-07162-1. | Click |
